Role of a Subdominant H-2Kd-Restricted SV40 Tumor Antigen Cytotoxic T Lymphocyte Epitope in Tumor Rejection
Identifieur interne : 003B28 ( Main/Exploration ); précédent : 003B27; suivant : 003B29Role of a Subdominant H-2Kd-Restricted SV40 Tumor Antigen Cytotoxic T Lymphocyte Epitope in Tumor Rejection
Auteurs : Romnie S. Newmaster ; Lawrence M. Mylin ; Tong-Ming Fu ; Satvir S. TevethiaSource :
- Virology [ 0042-6822 ] ; 1998.
English descriptors
- KwdEn :
- Teeft :
- Antigen, Antigen presentation, Assay, Bennink, Cancer inst, Cell line, Cell lines, Clone, Culture supplement, Cytotoxic, Cytotoxicity, Cytotoxicity assay, Cytotoxicity assays, Determinant, Dyldgsvkv, Effector, Efficient lysis, Eisenlohr, Encoding, Epitope, Histocompatibility, Immune response, Immunization, Immunocompetent mice, Immunol, Intrascapular region, K5rsv cells, Khtgsv, Khtgsv cells, Knowles, Lymphocyte, Lymphocyte clones, Lyse, Lyse cells, Lysed, Lysis, Major histocompatibility, Mksa, Mksa cells, Mksa stimulator cells, Mksa tumor cells, Mksa tumor challenge, Monoclonal antibodies, Mouse, Mylin, Natl, Newmaster, Nonimmunodominant epitopes, Partial protection, Peptide, Plasmid, Recombinant, Recombinant vaccinia virus, Recombinant vaccinia viruses, Release assay, Restimulated, Schirmbeck, Sequences encoding, Simian, Simian virus, Similar results, Specific lysis, Splenic lymphocytes, Splenocytes, Subdominant, Subdominant epitope, Subdominant epitopes, Synthetic peptide, Synthetic peptides, Tanaka, Target cells, Tevethia, Transgenic mice, Transplantation, Transplantation antigen, Transplantation immunity, Tumor antigen, Tumor cells, Tumor induction, Tumor rejection, Vaccinia, Vaccinia recombinants, Viral, Virol, Virology, Yewdell, Zarling.
Abstract
Abstract: SV40-transformed mKSA cells (H-2d) readily induce progressively growing tumors in adult syngeneic BALB/c mice while expressing the full complement ofH-2dMHC class I antigens. BALB/c mice previously immunized with SV40, soluble SV40 T antigen, or irradiated SV40-transformed syngeneic, allogeneic, or xenogeneic cells reject an mKSA tumor challenge even though these mice have been considered low- or nonresponders to T antigen due to difficulty in demonstrating SV40 T antigen-specific CTL. We have investigated the role of H-2d-restricted CTL in the rejection of SV40 tumors in BALB/c mice. Immunization of BALB/c mice with SV40 induced T antigen-specific CTL which were largely H-2Ld-restricted. However, following repeatedin vitrorestimulation with mKSA cells, CTL emerged which recognized a subdominant H-2Kd-restricted epitope corresponding to T antigen residues 499–507. Immunization of BALB/c mice with a recombinant vaccinia virus expressing the T499–507epitope provided partial protection against a challenge of syngeneic mKSA tumor cells and induced the generation of T499–507-specific CTL. These results indicate that a subdominant H-2Kd-restricted CTL epitope can participate in the rejection of SV40 tumors in BALB/c mice.
Url:
DOI: 10.1006/viro.1998.9148
Affiliations:
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BALB/c mice previously immunized with SV40, soluble SV40 T antigen, or irradiated SV40-transformed syngeneic, allogeneic, or xenogeneic cells reject an mKSA tumor challenge even though these mice have been considered low- or nonresponders to T antigen due to difficulty in demonstrating SV40 T antigen-specific CTL. We have investigated the role of H-2d-restricted CTL in the rejection of SV40 tumors in BALB/c mice. Immunization of BALB/c mice with SV40 induced T antigen-specific CTL which were largely H-2Ld-restricted. However, following repeatedin vitrorestimulation with mKSA cells, CTL emerged which recognized a subdominant H-2Kd-restricted epitope corresponding to T antigen residues 499–507. Immunization of BALB/c mice with a recombinant vaccinia virus expressing the T499–507epitope provided partial protection against a challenge of syngeneic mKSA tumor cells and induced the generation of T499–507-specific CTL. These results indicate that a subdominant H-2Kd-restricted CTL epitope can participate in the rejection of SV40 tumors in BALB/c mice.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fu, Tong Ming" sort="Fu, Tong Ming" uniqKey="Fu T" first="Tong-Ming" last="Fu">Tong-Ming Fu</name><name sortKey="Mylin, Lawrence M" sort="Mylin, Lawrence M" uniqKey="Mylin L" first="Lawrence M." last="Mylin">Lawrence M. Mylin</name><name sortKey="Newmaster, Romnie S" sort="Newmaster, Romnie S" uniqKey="Newmaster R" first="Romnie S." last="Newmaster">Romnie S. Newmaster</name><name sortKey="Tevethia, Satvir S" sort="Tevethia, Satvir S" uniqKey="Tevethia S" first="Satvir S." last="Tevethia">Satvir S. Tevethia</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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